Increased Risk of Monoclonal Gammopathy in First-Degree Relatives of Patients With Multiple Myeloma or Monoclonal Gammopathy of Undetermined Significance
Document Type
Article
Publication Date
11-19-2009
Description
We examined whether monoclonal gammopathy of undetermined significance (MGUS) is increased in first-degree relatives of multiple myeloma (MM) or MGUS patients. Probands were recruited from a population-based prevalence study (MGUS) and the Mayo Clinic (MM). Serum samples were collected from first-degree relatives older than 40 years and subjected to electrophoresis and immunofixation. The prevalence of MGUS in relatives was compared with population-based rates. Nine-hundred eleven relatives of 232 MM and 97 MGUS probands were studied. By electrophoresis, MGUS was detected in 55 (6%) relatives, and immunofixation identified 28 additional relatives for an age- and sex-adjusted prevalence of 8.1% (95% CI, 6.3 to 9.8). The prevalence of MGUS in relatives increased with age (1.9%, 6.9%, 11.6%, 14.6%, 21.0% for ages 40-49, 50-59, 60-69, 70-79, ≥ 80 years, respectively; P < .001). Using similar MGUS detection methods, there was a higher risk of MGUS in relatives (age-adjusted risk ratio [RR], 2.6; 95% CI, 1.9 to 3.4) compared with the reference population. The increased risk was seen among relatives of MM(RR, 2.0;95%CI, 1.4 to 2.8) and MGUS probands (RR, 3.3; 95% CI, 2.1 to 4.8). The increased risk of MGUS in first-degree relatives of MGUS or MM patients implies shared environment and/or genetics.
Citation Information
Vachon, Celine M.; Kyle, Robert A.; Therneau, Terry M.; Foreman, Barbara J.; Larson, Dirk R.; Colby, Colin L.; Phelps, Tara K.; Dispenzieri, Angela; Kumar, Shaji K.; Katzmann, Jerry A.; and Rajkumar, S. Vincent. 2009. Increased Risk of Monoclonal Gammopathy in First-Degree Relatives of Patients With Multiple Myeloma or Monoclonal Gammopathy of Undetermined Significance. Blood. Vol.114(4). 785-790. https://doi.org/10.1182/blood-2008-12-192575 PMID: 19179466 ISSN: 0006-4971