Comprehensive Mutation Scanning of LMNA in 268 Patients With Lone Atrial Fibrillation
Document Type
Article
Publication Date
5-15-2009
Description
Atrial fibrillation (AF) is a heritable, genetically heterogeneous disorder. To identify gene defects that cause or confer susceptibility to AF, a cohort of 268 unrelated patients with idiopathic forms of familial and sporadic AF was recruited. LMNA, encoding the nuclear membrane proteins, lamin A/C, was selected as a candidate gene for lone AF based on its established association with a syndrome of dilated cardiomyopathy, conduction system disease, and AF. Comprehensive mutation scanning identified only 1 potentially pathogenic mutation. In conclusion, LMNA mutations rarely cause lone AF and routine genetic testing of LMNA in these patients does not appear warranted.
Citation Information
Brauch, Katharine M.; Chen, Lin Y.; and Olson, Timothy M.. 2009. Comprehensive Mutation Scanning of LMNA in 268 Patients With Lone Atrial Fibrillation. American Journal of Cardiology. Vol.103(10). 1426-1428. https://doi.org/10.1016/j.amjcard.2009.01.354 PMID: 19427440 ISSN: 0002-9149