Document Type
Review
Publication Date
5-6-2010
Description
Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The task of exerting antipathogen activity by CD8+ T cells, which principally function to control and eradicate intracellular pathogens, is enabled by constitutive expression of MHC class-I molecules on all tissue types. CTL induction offers hope for vaccines against pathogens that are resistant to neutralizing activity. This review discusses the mechanism of immune induction by some successful vaccines and based on the accrued evidence suggests ideas for improved design of CTL-inducing vaccines.
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Citation Information
Kumaraguru, Uday; and Woolard, Stacie N.. 2010. Viral Vaccines and CTL Response. Journal of Biomedicine and Biotechnology. Vol.2010 https://doi.org/10.1155/2010/141657 PMID: 20379365 ISSN: 1110-7243
Copyright Statement
Copyright © 2010 Stacie N. Woolard and Uday Kumaraguru. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.