L-methionine Decreases Dendritic Spine Density in Mouse Frontal Cortex
Document Type
Article
Publication Date
6-1-2010
Description
Schizophrenia postmortem brain is characterized by γ aminobutyric acid downregulation and by decreased dendritic spine density in frontal cortex. Protracted L-methionine treatment exacerbates schizophrenia symptoms, and our earlier work (Tremolizzo et al. and Dong et al.) has shown that L-methionine decreases reelin and GAD67 transcription in mice which is prevented by co-administration of valproate. In this study, we observed a decrease in spine density following L-methionine treatment, which was prevented by co-administration of valproate. Together with our earlier findings conducted under the same experimental conditions, we suggest that downregulation of spine density in L-methionine-treated mice may be because of the decreased expression of reelin and that valproate may prevent spine downregulation by inhibiting the methylation induced decrease in reelin.
Citation Information
Tueting, Patricia; Davis, John M.; Veldic, Marin; Pibiri, Fabio; Kadriu, Bashkim; Guidotti, Alessandro; and Costa, Erminio. 2010. L-methionine Decreases Dendritic Spine Density in Mouse Frontal Cortex. NeuroReport. Vol.21(8). 543-548. https://doi.org/10.1097/WNR.0b013e3283373126 PMID: 20442623 ISSN: 0959-4965