Ontogenetic Manganese Exposure With Perinata 6-OHDA Lesioning Alters Behavioral Responses of Rats to Dopamine D1 and D2 Agonist Treatments
Document Type
Article
Publication Date
1-1-2014
Description
The effect of neonatal manganese (Mn) exposure in a 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease was investigated. Pregnant Wistar rats were given drinking water with 10,000ppm of Manganese (MnCl2.4H2O) from the time of conception until weaning on the 21st day after delivery. Control rats consumed tap water. Three days after the birth, other groups of neonatal rat pups were pretreated with desipramine (20mg/kg ip 1h) prior to bilateral ICV administration of 6-OHDA or its vehicle, saline-ascorbic (0.1%) (control). Two months after the birth, striatal dopamine and homovanilic acid efflux measured by an in vivo microdialysis method were reduced in rats lesioned with 6-OHDA. Co-exposure to perinatal Mn did not modify neurotransmission alterations. However, there were prominent abnormalities in behavioral testing in rats perinatally exposed to Mn and treated neonatally with 6-OHDA. These findings demonstrate that although Mn did not further damage neurotransmitter activity in the neostriatum, ontogenetic exposure to Mn enhances the behavioral toxicity to 6-OHDA.
Citation Information
Szkilnik, Ryszard; Brus, Ryszard; Malinowska-Borowska, Jolanta; Nowak, Damian; Waliczek, Martyna; Kostrzewa, Richard M.; and Nowak, Przemyslaw. 2014. Ontogenetic Manganese Exposure With Perinata 6-OHDA Lesioning Alters Behavioral Responses of Rats to Dopamine D1 and D2 Agonist Treatments. Environmental Toxicology and Pharmacology. Vol.37(1). 28-36. https://doi.org/10.1016/j.etap.2013.11.003 PMID: 24295730 ISSN: 1382-6689