Scavenger Receptor-A (CD204): A Two-Edged Sword in Health and Disease
Document Type
Article
Publication Date
1-1-2014
Description
Scavenger receptor A (SR-A), also known as the macrophage scavenger receptor and cluster of differentiation 204 (CD204), plays roles in lipid metabolism, atherogenesis, and a number of metabolic processes. However, recent evidence points to important roles for SR-A in infammation, innate immunity, host defense, sepsis, and ischemic injury. Herein, we review the role of SR-A in infammation, innate immunity, host defense, sepsis, cardiac and cerebral ischemic injury, Alzheimer's disease, virus recognition and uptake, bone metabolism, and pulmonary injury. Interestingly, SR-A is reported to be host protective in some disease states, but there is also compelling evidence that SR-A plays a role in the pathophysiology of other diseases. These observations of both harmful and beneficial effects of SR-A are discussed here in the framework of inflammation, innate immunity, and endoplasmic reticulum stress.
Citation Information
Kelley, Jim L.; Ozment, Tammy R.; Li, Chuanfu; Schweitzer, John B.; and Williams, David L.. 2014. Scavenger Receptor-A (CD204): A Two-Edged Sword in Health and Disease. Critical Reviews in Immunology. Vol.34(3). 241-261. https://doi.org/10.1615/CritRevImmunol.2014010267 PMID: 24941076 ISSN: 1040-8401