Synthesis and Characterization of Valyloxy Methoxy Luciferin for the Detection of Valacyclovirase and Peptide Transporter
Document Type
Article
Publication Date
10-15-2014
Description
An amino acid ester derivative of luciferin (valoluc) was synthesized to mimic the transport and activation of valacyclovir. This molecule was characterized in vitro for specificity and enzymatic constants, and then assayed in two different, physiologically-relevant conditions. It was demonstrated that valoluc activation is sensitive to the same cellular factors as valacyclovir and thus has the potential to elucidate the dynamics of amino acid ester prodrug therapies in a functional, high-throughput manner.
Citation Information
Walls, Zachary F.; Gupta, Sheeba Varghese; Amidon, Gordon L.; and Lee, Kyung Dall. 2014. Synthesis and Characterization of Valyloxy Methoxy Luciferin for the Detection of Valacyclovirase and Peptide Transporter. Bioorganic and Medicinal Chemistry Letters. Vol.24(20). 4781-4783. https://doi.org/10.1016/j.bmcl.2014.09.011 PMID: 25240255 ISSN: 0960-894X