Document Type
Article
Publication Date
1-1-2015
Description
The naked mole-rat possesses several unique physiological and molecular features that underlie their remarkably and exceptional resistance to tissue hypoxia. Elevated pattern of Epo, an erythropoietin (Epo) factor; c-fos; vascular endothelial growth factor (VEGF); and hypoxia-inducible factors (HIF-1α) contribute to the adaptive strategy to cope with hypoxic stress. Moreover, the naked mole-rat has a lower metabolic rate than any other eutherian mammal of comparable size that has been studied. The ability to actively reduce metabolic rate represents a strategy widely used in the face of decreased tissue oxygen availability. Understanding the different molecular and physiological factors that induce metabolic suppression could guide the development of pharmacological agents for the clinical management of stroke patient.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Citation Information
Nathaniel, Thomas I.; Soyinka, Julius O.; Adedeji, Adekunle; and Imeh-Nathaniel, Adebobola. 2015. Molecular and Physiological Factors of Neuroprotection in Hypoxia-Tolerant Models: Pharmacological Clues for the Treatment of Stroke. Journal of Experimental Neuroscience. Vol.9(1). 1-5. https://doi.org/10.4137/JEN.S22512
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