The Rewarding Properties of Methamphetamine in an Invertebrate Model of Drug Addiction
Document Type
Article
Publication Date
1-1-2016
Description
The rewarding properties of drugs in the mammalian system depend on their ability to activate appetitive motivational states. The associated underlying mechanism is strongly conserved in evolution and invertebrates have recently emerged as a powerful new model in addiction research. The natural reward system in crayfish has surprisingly proven sensitive to human drugs of abuse, providing a new model for research into the basic biological mechanisms of drug addiction. In this study, we examined the presence of natural reward systems in crayfish, and then characterized its sensitivity to 2.5 μg/g, 5.0 μg/g and 10.0 μg/g doses of methamphetamine (METH). Using the conditioned place preference (CPP) paradigm, we demonstrated that irrespective of the number of doses of METH injected into the pericardial system, crayfish seek out a particular tactile environment that had previously been paired with the METH. This study demonstrates that crayfish offer a comparative and complementary approach in addiction research. It contributes an evolutionary context to our understanding of a key component in learning and of natural reward as an important life-sustaining process.
Citation Information
Imeh-Nathaniel, Adebobola; Adedeji, Adekunle; Huber, Robert; and Nathaniel, Thomas I.. 2016. The Rewarding Properties of Methamphetamine in an Invertebrate Model of Drug Addiction. Physiology and Behavior. Vol.153 40-46. https://doi.org/10.1016/j.physbeh.2015.10.017 PMID: 26477734 ISSN: 0031-9384