Title
Dectin-1 Plays a Redundant Role in the Immunomodulatory Activities of β-Glucan-Rich Ligands in Vivo
Document Type
Article
Publication Date
6-1-2013
Description
β-Glucans are known for their ability to trigger both protective and damaging immune responses. Here we have explored the role of the beta-glucan receptor Dectin-1 in archetypical models of protective and non-protective immunomodulation induced by beta-glucan rich ligands. In the first model, we explored the role of Dectin-1 in the ability of soluble purified β-glucans to mediate protection against systemic Staphylococcus aureus infection in mice. In the second model, we explored the role of Dectin-1 in zymosan induced multiple organ dysfunction syndrome. In both cases, these β-glucan rich compounds had marked effects invivo which were unaltered by Dectin-1 deficiency, suggesting that this receptor has a redundant role in these murine models.
Citation Information
Marakalala, Mohlopheni J.; Williams, David L.; Hoving, Jennifer C.; Engstad, Rolf; Netea, Mihai G.; and Brown, Gordon D.. 2013. Dectin-1 Plays a Redundant Role in the Immunomodulatory Activities of β-Glucan-Rich Ligands in Vivo. Microbes and Infection. Vol.15(6-7). 511-515. https://doi.org/10.1016/j.micinf.2013.03.002 PMID: 23518266 ISSN: 1286-4579