Cellular Cardiomyoplasty: Its Past, Present, and Future
Document Type
Article
Publication Date
7-18-2013
Description
Cellular cardiomyoplasty is a cell therapy using stem cells or progenitor cells for myocardial regeneration to improve cardiac function and mitigate heart failure. Since we first published cellular cardiomyoplasty in 1989, this procedure became the innovative method to treat damaged myocardium other than heart transplantation. A significant improvement in cardiac function, metabolism, and perfusion is generally observed in experimental and clinical studies, but the improvement is mild and incomplete. Although safety, feasibility, and efficacy have been well documented for the procedure, the beneficial mechanisms remain unclear and optimization of the procedure requires further study. This chapter briefly reviews the stem cells used for cellular cardiomyoplasty and their clinical outcomes with possible improvements in future studies.
Citation Information
Lamb, Elizabeth K.; Kao, Grace W.; and Kao, Race L.. 2013. Cellular Cardiomyoplasty: Its Past, Present, and Future. Methods in Molecular Biology. Vol.1036 1-17. https://doi.org/10.1007/978-1-62703-511-8_1 PMID: 23807782 ISSN: 1064-3745 ISBN: 9781627035101