Enhanced Ganglionic Responses to Substance P in Spontaneously Hypertensive Rats
Document Type
Article
Publication Date
1-1-2000
Description
Intravenous injection of substance P (SP) increases blood pressure in normotensive rats by stimulating sympathetic ganglia. This study compared the effects of SP to increase renal nerve firing and blood pressure in normotensive and hypertensive rats treated with chlorisondamine. The increase in renal nerve firing was greatest in spontaneously hypertensive rats (SHR), intermediate in Wistar rats, and least in Wistar-Kyoto (WKY) rats. Blood pressure was increased more in SHR than in Wistar rats. Blood pressure was not increased in WKY rats. Responses to the ganglionic stimulant 1, 1-dimethyl-4-phenylpiperazinium were the same in the three strains. These results suggest that there is a selective increase in the action of SP on sympathetic ganglia of SHR and that ganglion responsiveness to SP is correlated with its effect on blood pressure.
Citation Information
Hancock, John C.; and Lindsay, Gregory W.. 2000. Enhanced Ganglionic Responses to Substance P in Spontaneously Hypertensive Rats. Peptides. Vol.21(4). 535-541. https://doi.org/10.1016/S0196-9781(00)00170-4 PMID: 10822109 ISSN: 0196-9781