7-OH-DPAT, Unlike Quinpirole, Does Not Prime a Yawning Response in Rats
Document Type
Article
Publication Date
12-18-2000
Description
Repeated treatment in ontogeny with the dopamine (DA) D2/D3 receptor agonist quinpirole is associated with enhanced quinpirole-induced yawning and other behaviors such as vacuous chewing, vertical jumping, and antinociception. To determine if the reputedly DA D3 agonist (±)-2-(dipropylamino)-7-hydroxy-1,2,3,4-tetrahydronaphthalene (7-OH-DPAT) would prime for yawning in a manner analogous to that for quinpirole, rats were treated for the first 11 days after birth with an equimolar dose of either quinpirole or 7-OH-DPAT (195.4 nmol/kg/day) and tested for agonist-induced yawning in adulthood. While enhanced quinpirole-induced and 7-OH-DPAT-induced yawning was observed in quinpirole-primed rats, acute treatments with quinpirole and 7-OH-DPAT did not produce an enhanced yawing response in 7-OH-DPAT-'primed' rats. Our findings indicate that 7-OH-DPAT, unlike quinpirole, does not prime for quinpirole- or 7-OH-DPAT-induced yawning in rats.
Citation Information
Oswiecimska, Joanna; Brus, Ryszard; Szkilnik, Ryszard; Nowak, Przemysław; and Kostrzewa, Richard M.. 2000. 7-OH-DPAT, Unlike Quinpirole, Does Not Prime a Yawning Response in Rats. Pharmacology Biochemistry and Behavior. Vol.67(1). 11-15. https://doi.org/10.1016/S0091-3057(00)00296-3 PMID: 11113478 ISSN: 0091-3057