Role of Toll-Like Receptors in Myocardial Ischemia/Reperfusion Injury
Document Type
Book Contribution
Publication Date
1-1-2013
Description
Engagement of the innate immune system and activation of inflammatory responses have been demonstrated to play an important role in myocardial ischemia/reperfusion (I/R) injury (Barry 1994; Bryant et al. 1998; Frangogiannis 2006; Kubota et al. 1997) and congestive heart failure (CHF) (Torre-Amione et al. 1996). Experimental studies and clinical investigations have shown that I/R significantly increases myocardial inflammatory cytokine expression including TNF-α, IL-1β, IL-6, IL-8, interferon-γ (IFN-γ), and intercellular adhesion molecule-1 (I-CAM-1) (Barry 1994; Bryant et al. 1998; Frangogiannis 2006; Kubota et al. 1997; Kukielka et al. 1995). These proinflammatory cytokines are directly involved in the progression of myocardial I/R injury, myocardial dysfunction, vascular wall remodeling, and heart failure (Kelly and Smith 1997; Ono et al. 1998). However, we still do not fully understand the mechanisms by which the innate immune and inflammatory responses are involved in ischemic heart diseases.
Citation Information
Ha, Tuanzhu; Liu, Li; Kelley, Jim; Williams, David; and Li, Chuanfu. 2013. Role of Toll-Like Receptors in Myocardial Ischemia/Reperfusion Injury. Cardiovascular Diseases: Nutritional and Therapeutic Interventions. 123-142. ISBN: 9781439882016,9781439882009