Clinical Cellular Cardiomyoplasty: Technical Considerations
Document Type
Conference Proceeding
Publication Date
5-1-2003
Description
Three patients, all with a history of coronary heart disease, underwent coronary artery bypass grafting and implantation of autologous satellite cells. Satellite cells were isolated from muscle biopsies of the right vastus lateralis muscle after enzymatic treatment. While the heart was still under hypothermic cardioplegia, 4 mL of cell suspension divided into approximately 40 doses was injected into the ventricular wall of the ischemic area. Less than 5 minutes were required to complete the cell implantation. All patients survived the procedure, without obvious arrhythmia, had an uneventful recovery, and were discharged from the hospital. At 3 to 4 months follow-up examination, increased left ventricular ejection fraction, decreased left ventricular diastolic diameter, as well as improved ventricular wall thickness and perfusion at the satellite cell implantation sites were observed. Our experience indicated the safety and early benefit of cellular cardiomyoplasty using autologous satellite cells.
Citation Information
Zhang, Fumin; Yang, Zhijian; Chen, Yijiang; Qin, Jianwei; Zhu, Tiebing; Xu, Di; Xu, Zhaoqiang; Xu, Qingbin; Qian, Yi; Ma, Wenzhu; Chen, Lizhen; Gao, Xiang; Li, Chuanfu; Ha, Tuanzhu; and Kao, Race L.. 2003. Clinical Cellular Cardiomyoplasty: Technical Considerations. Journal of Cardiac Surgery. Vol.18(3). 268-273. https://doi.org/10.1046/j.1540-8191.2003.02043.x PMID: 12809404 ISSN: 0886-0440