Oxidative Damage to Cytosine: Implication for the Study of Radiation-Induced Damage to DNA
Document Type
Article
Publication Date
1-23-2003
Description
A radical observed in irradiated single crystals of cytidine, 3′-CMP, and 5′-dCMP is characterized by three anisotropic proton hyperfine couplings and is called the 3αH radical. The 3αH radical shares properties with the allyl-like radical observed in thymine derivatives. The goal of the present work is to show that the previously observed 3αH radicals are cytosine base radicals formed on 5-methylcytosine impurities in these crystals. Ab initio electron propagator calculations in the partial third-order (P3) approximation with the 6-311G(d,p) basis set have been used to show that these 5-methylcytosines are good hole traps, having an ionization potential comparable to that of guanine. The importance of these cytosine oxidation sites to the radiation chemistry of DNA is discussed.
Citation Information
Close, David M.. 2003. Oxidative Damage to Cytosine: Implication for the Study of Radiation-Induced Damage to DNA. Journal of Physical Chemistry B. Vol.107(3). 864-867. https://doi.org/10.1021/jp022056g ISSN: 1089-5647