Metastin-Like Immunoreactivity in the Rat Medulla Oblongata and Spinal Cord
Document Type
Article
Publication Date
1-2-2003
Description
Metastin, the product of metastasis suppressor gene KiSS-1, is proposed to be the natural ligand for the G-protein-coupled receptor GPR54, known also as AXOR12. This immunohistochemical study, using a rabbit polyclonal antiserum against the human metastin fragment (45-54)-NH2, showed that in rats metastin-like immunoreactivity (MTS-LI) was present in neurons of the nucleus of the solitary tract and caudoventrolateral reticular nucleus, and in cell processes of the spinal trigeminal tract and lateral reticular nucleus. MTS-LI was confined mainly to neurons and fibers at or caudal to the area postrema. In the spinal cord, MTS-LI cell processes formed a dense plexus in superficial layers I and II of the dorsal horn. The pattern of distribution of MTS-LI in the medulla and spinal cord suggests that this novel peptide may participate in autonomic and sensory neural signaling.
Citation Information
Dun, Siok L.; Brailoiu, G. Cristina; Parsons, Amy; Yang, Jun; Zeng, Qiang; Chen, Xiangqun; Chang, Jaw Kang; and Dun, Nae J.. 2003. Metastin-Like Immunoreactivity in the Rat Medulla Oblongata and Spinal Cord. Neuroscience Letters. Vol.335(3). 197-201. https://doi.org/10.1016/S0304-3940(02)01191-6 PMID: 12531466 ISSN: 0304-3940