Involvement of β-Arrestin-2 in Modulation of the Spinal Antinociception Induced by μ-Opioid Receptor Agonists in the Mouse
Document Type
Article
Publication Date
7-31-2003
Description
Beta-arrestins have been suggested to regulate μ-, δ-, and κ-opioid receptor-mediated responses. In the present study, we examined the effects of pretreatment with β-arrestin-2 antibody on tail-flick inhibition induced by opioid receptor agonists in the mouse spinal cord. Intrathecal (i.t.) pretreatment with β-arrestin-2 antibody potentiated the antinociception induced by i.t.-administered μ-opioid receptor agonists [D-Ala2,NMePhe4,Gly-ol5]enkephalin (DAMGO) and endomorphin-1, but not endomorphin-2, the δ-opioid receptor agonist [D-Ala2]deltorphin II or the κ-opioid receptor agonist U50,488H. The present result suggests that β-arrestin-2 may tonically down-regulate a selected population of μ-opioid receptors activated by endomorphin-1 or DAMGO in the mouse spinal cord.
Citation Information
Ohsawa, Masahiro; Mizoguchi, Hirokazu; Narita, Minoru; Nagase, Hiroshi; Dun, Nae J.; and Tseng, Leon F.. 2003. Involvement of β-Arrestin-2 in Modulation of the Spinal Antinociception Induced by μ-Opioid Receptor Agonists in the Mouse. Neuroscience Letters. Vol.346(1-2). 13-16. https://doi.org/10.1016/S0304-3940(03)00591-3 PMID: 12850536 ISSN: 0304-3940