Angiotensin II and Related Peptides Alter Liposomal Membrane Fluidity
Document Type
Article
Publication Date
1-1-1998
Description
We investigated the effects of angiotensinogen (Ang), angiotensin I (Ang I), and angiotensin II (Ang II) on the fluidity of phosphatidylcholine vesicles. Changes in fluidity were assessed by changes in anisotopy values calculated from fluorescence polarization measurements. All three compounds produced an increase in membrane fluidity when localized inside the phosphatidylcholine vesicles. When placed outside the vesicles. Ang II increased bilayer rigidity (decreased fluidity), whereas Ang and Ang I produced no effect. These results suggest the possibility that these peptides may alter the fluidity of cell membranes by a direct action on the phospholipid bilayer, which may in turn interfere with receptor-mediated effects.
Citation Information
Brailoiu, Eugen; Margineanu, Anca; and Miyamoto, Michael D.. 1998. Angiotensin II and Related Peptides Alter Liposomal Membrane Fluidity. Biochemistry and Molecular Biology International. Vol.44(1). 203-209. https://doi.org/10.1080/15216549800201222 PMID: 9503164 ISSN: 1039-9712