Heterogeneity of Endothelial Cell Function for Angiotensin Conversion in Serial-Arranged Arterioles
Document Type
Article
Publication Date
1-1-1995
Description
The involvement of the endothelial cell in the vasoconstriction induced by angiotensin I and II (AI, AII), and norepinephrine (NE) was studied in microvessels of the hamster cheek pouch before and after the following procedures: endothelial impairment by light-dye treatment, inhibition of angiotensin-converting enzyme (ACE), blockade of endothelium-derived relaxing factor (EDRF) and inhibiting prostaglandin (PG) synthesis. The results showed that in large 2nd-order arterioles, endothelial impairment did not affect the vasoconstrictor activity of AII and NE, nor did it alter ACE activity. However, in small 4th-order arterioles, endothelial impairment significantly reduced angiotensin conversion without altering the vasoconstrictor responses to either AII or NE. Thus, the endothelium plays differential roles in the modulation of local angiotensin conversion in these distinct segments of serial-arranged arterioles. Furthermore, it is unlikely that the vasoconstrictor response to AII in these arterioles is modulated by the endothelium through a pathway involving the release of EDRF or PGs.
Citation Information
Tang, T.; Conelly, B. A.; and Joyner, W. L.. 1995. Heterogeneity of Endothelial Cell Function for Angiotensin Conversion in Serial-Arranged Arterioles. Journal of Vascular Research. Vol.32(2). 129-137. https://doi.org/10.1159/000159087 PMID: 7734659 ISSN: 1018-1172