Title
Synthesis of Iron-Binding Oligonucleotides and Their Reactions With Single-Stranded DNA
Document Type
Article
Publication Date
1-1-1993
Description
Two 12-base oligonucleotides were synthesized and modified by attaching metal-binding ligands (2,6-pyridinedicarboxylate and 2,2′-dipicolylamine) to their 5′-ends. When hybridized to a 135-base single stranded DNA, in the presence of Fe2+, O2, and a reducing agent, these obligonucleotides cleaved the complementary DNA chain with unique and high base-sequence specificities.
Citation Information
Kady, Ismail O.; and Groves, John T.. 1993. Synthesis of Iron-Binding Oligonucleotides and Their Reactions With Single-Stranded DNA. Bioorganic and Medicinal Chemistry Letters. Vol.3(6). 1367-1370. https://doi.org/10.1016/S0960-894X(00)80350-9 ISSN: 0960-894X