Macrophage Activation by T Cells: Cognate and Non-Cognate Signals
Document Type
Article
Publication Date
1-1-1993
Description
Both tumor necrosis factor-α and interferon-γ are involved in the activation of macrophage cytocidal/cytostatic effector function. Recent studies provide evidence that, in non-septic inflammatory disease, T cells may activate macrophages primed by interferon-γ either by providing tumor necrosis factor-α (in soluble or membrane-anchored form) or by inducing macrophage tumor necrosis factor-α production by antigen-non-specific cognate interactions. Conversely, T cells may inhibit macrophage activation by producing cytokines that inhibit either tumor necrosis factor-α production or interferon-γ receptor signaling.
Citation Information
Stout, Robert D.. 1993. Macrophage Activation by T Cells: Cognate and Non-Cognate Signals. Current Opinion in Immunology. Vol.5(3). 398-403. https://doi.org/10.1016/0952-7915(93)90059-2 PMID: 8394092 ISSN: 0952-7915