Comparative Activity of Meropenem (SM-7338) Against Major Respiratory Pathogens and Amikacin-Resistant Nosocomial Isolates
Document Type
Article
Publication Date
1-1-1992
Description
Meropenem, a new broad-spectrum carbapenem antibiotic, demonstrated excellent in vitro activity against major respiratory pathogens including Moraxella catarrhalis, Haemophilus influenzae and Streptococcus pneumoniae. Minimal inhibitory concentrations of meropenem for Moraxella catarrhalis and Haemophilus influenzae isolates were frequently less than those of imipenem. For nosocomial amikacin-resistant gram-negative bacilli, meropenem had eightfold lower MIC90 values compared to imipenem against strains of Serratia marcescens, Enterobacter cloacae and Escherichia coli; it was 32-fold more active than imipenem against Proteus mirabilis isolates. Activity was similar to that of imipenem against Pseudomonas aeruginosa isolates. Overall, meropenem showed excellent activity against common community-acquired pathogens as well as amikacin-resistant nosocomial pathogens.
Citation Information
Sarubbi, F.; Franzus, B.; and Verghese, A.. 1992. Comparative Activity of Meropenem (SM-7338) Against Major Respiratory Pathogens and Amikacin-Resistant Nosocomial Isolates. European Journal of Clinical Microbiology andamp; Infectious Diseases. Vol.11(1). 65-68. https://doi.org/10.1007/BF01971276 PMID: 1563388 ISSN: 0934-9723