Mast Cell Tryptase Is Increased in the Nasal and Bronchoalveolar Lavage Fluids of Humans After Ozone Exposure
Document Type
Article
Publication Date
1-1-1993
Description
Human mast cell tryptase, a marker for mast cell degranulation, was immunologically measured in nasal lavage fluids (NALF) and bronchoalveolar lavage fluids (BALF) from subjects exposed to 0.4 ppm ozone (O3) for 2 hr with intermittent exercise. Tryptase antigen was significantly elevated in the NALF immediately postexposure to O3 (p -0008) in comparison to samples taken immediately after exposure to air. Additionally, an examination of data from five subjects, serving as their own controls, revealed elevated tryptase levels immediately postexposure (p -015) and 18 hr after exposure (p -026), in comparison to corresponding samples obtained with air exposure. An examination of BALF samples (n - 9) from these same subjects 18 hr after exposure showed that tryptase was significantly (p -01) elevated. These data suggest that O3 exposure results in mast cell degranulation and that mast cell-derived mediators may contribute to the physiological effects noted with O3 inhalation.
Citation Information
Smith, Craig E.; Koren, Hillel S.; Graham, Delores G.; and Johnson, David A.. 1993. Mast Cell Tryptase Is Increased in the Nasal and Bronchoalveolar Lavage Fluids of Humans After Ozone Exposure. Inhalation Toxicology. Vol.5(1). 117-127. https://doi.org/10.3109/08958379309034497 ISSN: 0895-8378