The Effect of Hamster Age on u.v.-Induced Unscheduled DNA Synthesis in Freshly Isolated Lung and Kidney Cells
Document Type
Article
Publication Date
1-1-1981
Description
The percentages of hamster lung and kidney cells exhibiting u.v.-induced unscheduled DNA synthesis (UDS) and the mean grain counts of repairing cells remain generally similar from the age of 9 days to more than 520 days. This period comprises 2/3 of the maximum life span of this hamster strain. Repair synthesis is approx. 2-fold higher in lung cells than in kidney cells. Absence of a systematic decrease in UDS with age suggests that decline of excision repair capacity is not an important factor in normal aging. A significant increase in the proportion of irradiated lung and kidney cells exhibiting u.v.-induced UDS occurs between days 4 and 9. This may represent a developmental regulation of DNA repair.
Citation Information
Gensler, Helen L.. 1981. The Effect of Hamster Age on u.v.-Induced Unscheduled DNA Synthesis in Freshly Isolated Lung and Kidney Cells. Experimental Gerontology. Vol.16(1). 59-68. https://doi.org/10.1016/0531-5565(81)90009-7 PMID: 7215481 ISSN: 0531-5565