Characterization of an Evolutionarily Old Human Alphoid DNA

Creator(s)

Susan L. Carnahan, Loyola University of Chicago
Eleni Palamidis-Bourtsos, Loyola University of Chicago
Phillip R. Musich, Quillen-Dishner College of MedicineFollow
Jeffrey L. Doering, Loyola University of Chicago

Document Type

Article

Publication Date

1-30-1993

Description

A recently isolated human alphoid DNA (in plasmid pHH550) has been sequenced and found to have an exceptionally high degree of similarity to the human alphoid consensus sequence, while its component monomers are unusually heterogeneous in sequence. In contrast to other alphoid DNAs, this DNA is found in all primates tested. Thus this may be an evolutionarily old sequence similar to the one from which other human alphoid DNAs diverged. The pHH550 sequences are found on a number of human chromosomes, including 21 and 22. On chromosome 21 most members of this new sequence group are located distal to other alphoid DNAs.

Citation Information

Carnahan, Susan L.; Palamidis-Bourtsos, Eleni; Musich, Phillip R.; and Doering, Jeffrey L.. 1993. Characterization of an Evolutionarily Old Human Alphoid DNA. Gene. Vol.123(2). 219-225. https://doi.org/10.1016/0378-1119(93)90127-O PMID: 8428661 ISSN: 0378-1119