Enhancement of Sprouting and Putative Regeneration of Central Noradrenergic Fibers by Morphine
Document Type
Article
Publication Date
1-1-1980
Description
Treatment of newborn rats with 6-hydroxydopa (6-OHDOPA, 60 μg/g IP) increased the levels of norepinephrine in the adult cerebellum and hindbrain. Concurrent treatment with morphine sulfate (20 μg/g IP) potentiated the response to 6-OHDOPA in the cerebellum and pons-medulla. In addition, increased noradrenergic neurite density in 4 week cerebellar cortex (as observed with histofluorescent staining by glyoxylic acid) suggests that neonatal morphine increased the sprouting of noradrenergic neurons in the 6-OHDOPA treated rats.
Citation Information
Harston, Craig T.; Morrow, Anne; and Kostrzewa, Richard M.. 1980. Enhancement of Sprouting and Putative Regeneration of Central Noradrenergic Fibers by Morphine. Brain Research Bulletin. Vol.5(4). 421-424. https://doi.org/10.1016/S0361-9230(80)80012-8 PMID: 7407638 ISSN: 0361-9230