Direct Modification of Plasma Low-Density Lipoproteins in Interstitial Inflammatory Fluid of the Rabbit
Document Type
Article
Publication Date
12-1-1984
Description
Utilizing the polyvinyl sponge-implant model in the rabbit, we have previously demonstrated modification in low-density lipoproteins (LDL) in the extravascular space in association with a cellular inflammatory response. In an attempt to isolate the source of these modifications, plasma LDL was labeled with125I, and introduced directly into the extravascular space at the time of sponge implantation. [125I] plasma LDL recovered from interstitial inflammatory fluid (IF) at 24 h after implantation demonstrated increased electrophoretic mobility as well as heterogeneity in particle size and hydrated density. These results are in agreement with our previous observations and indicate that modification in IF-LDL probably occurs after it has entered the extravascular space across the vascular wall.
Citation Information
Raymond, Thomas L.; and Reynolds, Scott A.. 1984. Direct Modification of Plasma Low-Density Lipoproteins in Interstitial Inflammatory Fluid of the Rabbit. Inflammation. Vol.8(4). 337-342. https://doi.org/10.1007/BF00918210 PMID: 6519774 ISSN: 0360-3997