Orexin a-Like Immunoreactivity in the Rat Brain
Document Type
Article
Publication Date
2-5-1999
Description
Distribution of orexin-A-like immunoreactivity (ORX-LI) in rat brains was investigated with the use of a rabbit polyclonal antibody against the full length peptide orexin A. Virtually all the ORX-LI cell bodies were observed in the lateral hypothalamus at the level of median eminence. The large majority of ORX-LI neurons appeared spherical or fusiform, 20-30 μm in diameter and issued two to five cell processes with few secondary branchings. Numerous ORX-LI fibers were observed in subregions of the hypothalamus. ORX- LI cell processes were sparsely distributed in the cortex, hippocampus and thalamus. Many varicose ORX-LI cell processes were situated close to the 3rd and lateral ventricles, some of which appeared to be protruding into the lumen. As a corollary, orexin A may be released into the ventricles and interact with neurons in distant targets, in addition to influencing the activity of neurons with which ORX-LI axons make synaptic contacts.
Citation Information
Chen, C. T.; Dun, S. L.; Kwok, E. H.; Dun, N. J.; and Chang, J. K.. 1999. Orexin a-Like Immunoreactivity in the Rat Brain. Neuroscience Letters. Vol.260(3). 161-164. https://doi.org/10.1016/S0304-3940(98)00977-X PMID: 10076892 ISSN: 0304-3940