Comparative Metabolism and Dna Binding of 7,12-Dimethylbenz[a]Anthracene and Its Weakly Carcinogenic 5-Fluoro Analog
Document Type
Article
Publication Date
1-1-1979
Description
Cultured Syrian hamster embryo cells readily convert both the carcinogenic polycyclic aromatic hydrocarbon, 7,12-dimethylbenz[a] anthracene (DMBA), and its weakly carcinogenic analogue, 5-fluoro-7,12-dimethylbenz[a] anthracene (5F-DMBA), to water soluble metabolites. DMBA, however, binds to the hamster cell DNA at least 2.8-3.0 times more extensively than 5F-DMBA. Likewise, 5F-DMBA is converted to water soluble metabolites by liver microsomal preparations at a rate equal to DMBA, but the latter compound binds to DNA 2.6-3.2 times more effectively.
Citation Information
Daniel, F. B.; Cazer, Frederick D.; D'Ambrosio, Steven M.; Hart, Ronald W.; Kim, Won Ho; and Witiak, Donald T.. 1979. Comparative Metabolism and Dna Binding of 7,12-Dimethylbenz[a]Anthracene and Its Weakly Carcinogenic 5-Fluoro Analog. Cancer Letters. Vol.6(4-5). 263-272. https://doi.org/10.1016/S0304-3835(79)80044-0 ISSN: 0304-3835