The Toxicology of Chemical Interactions During Pregnancy in the Mouse: Caffeine and Phenytoin
Document Type
Article
Publication Date
2-14-1984
Description
The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation. Caffeine, over a range of dosages, showed limited embryotoxic activity. Phenytoin was also weakly teratogenic and dosages needed to elicit embryotoxicity were accompanied by a significant increase in maternal lethality. Pretreatment with caffeine enhanced phenytoin-induced toxicity and teratogenicity and these observations confirm that caffeine has the ability to function as a coteratogen. Pretreatment with phenytoin produced a significant increase in maternal lethality following caffeine administration but no co-teratogenic effect. It is suggested that these results are the consequence of a yet undefined interaction at critical receptor sites in the maternal-embryo unit.
Citation Information
Skalko, R. G.; Poche, P. D.; and Kwasigroch, Thomas E.. 1984. The Toxicology of Chemical Interactions During Pregnancy in the Mouse: Caffeine and Phenytoin. Toxicology. Vol.30(1). 7-16. https://doi.org/10.1016/0300-483X(84)90057-X PMID: 6701907 ISSN: 0300-483X
