The Role of Selenium in the Secretion of Very-Low-Density Lipoprotein in the Isolated Perfused Rat Liver
Document Type
Article
Publication Date
1-1-1991
Description
A recirculating liver perfusion system was used to study the effects of dietary selenium (Se) on the hepatic secretion of very-low-density lipoprotein (VLDL). The perfusate from livers of rats fed on a Se-deficient diet incorporated about 50 % more [1-14C]oleic acid into triacylglycerol (TG) and cholesteryl esters (ChoEs) than did the perfusate from livers of rats fed on a Se-supplemented diet. Similarly, livers from rats fed the Se-deficient diet secreted more VLDL and incorporated about 60 %, more [1-14C]oleic acid into VLDL TG and ChoEs than did livers from rats fed the Se-supplemented diet. The liver perfusate from rats in the Se-deficient group also showed significantly decreased fatty acid oxidation. We conclude that Se is a potent modulator of lipoprotein metabolism. A primary action of Se deficiency appears to be a decrease in fatty acid oxidation and a stimulation of fatty acid esterification, leading to increased VLDL TG and ChoEs formation and secretion.
Citation Information
Scott, R. L.; Kheshti, A.; Heimberg, M.; Wilcox, H. G.; and Stone, W. L.. 1991. The Role of Selenium in the Secretion of Very-Low-Density Lipoprotein in the Isolated Perfused Rat Liver. Biochemical Journal. Vol.279(3). 741-745. https://doi.org/10.1042/bj2790741 PMID: 1953666 ISSN: 0264-6021