Brain Peptide Reverses Effect of Morphine on Human Lymphocytes
Document Type
Article
Publication Date
1-1-1987
Description
E-rosette formation by human lymphocytes incubated with sheep red blood cells (sRBC) is inhibited by morphine. We studied the ability of the opiate antagonists naloxone and Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) to block this action. Active E-rosette formation by lymphocytes incubated with morphine was reduced from the control of 35.7±1.7% to 23.7±1.5% (p<0.001). Similarly, total E-rosette formation was reduced by morphine from the control of 65.8±1.3% to 53.2±2.9% (p<0.001). These effects were blocked by co-incubation of the lymphocytes with either Tyr-MIF-1 or naloxone (p<0.05). Tyr-MIF-1 was active (p<0.05) at concentrations as dilute as 10-13M. These results indicate that the neuropeptide Tyr-MIF-1 exerts an antiopiate effect at the human T-lymphocyte.
Citation Information
Strimas, John H.; Chi, David S.; and Kastin, Abba J.. 1987. Brain Peptide Reverses Effect of Morphine on Human Lymphocytes. Peptides. Vol.8(6). 1165-1167. https://doi.org/10.1016/0196-9781(87)90148-3 PMID: 2894648 ISSN: 0196-9781