Effects of Guinea Pig Vasoactive Intestinal Peptide on the Isolated Perfused Guinea Pig Heart
Document Type
Article
Publication Date
1-1-1989
Description
The parmacological effects of guinea pig vasoactive intestinal peptide (VIP) were studied in isolated perfused guinea pig hearts. Bolus injections of VIP produced a dose-dependent tachycardia that was not affected by atenolol. A decrease in amplitude of ventricular contractions occurred in response to all doses of VIP. This response was preceded by a small increase in amplitude in 3 of 6 hearts at the highest dose. VIP produced a decrease in perfusion pressure which was prominent after coronary tone was elevated with [Arg8]-vasopressin. The present findings support speculation that VIP may have a role in the regulation of heart rate and coronary blood flow.
Citation Information
Hoover, Donald B.. 1989. Effects of Guinea Pig Vasoactive Intestinal Peptide on the Isolated Perfused Guinea Pig Heart. Peptides. Vol.10(2). 343-347. https://doi.org/10.1016/0196-9781(89)90041-7 PMID: 2755874 ISSN: 0196-9781