Effects of Spantide on Guinea Pig Coronary Resistance Vessels
Document Type
Article
Publication Date
1-1-1991
Description
Effects of spantide ([D-Arg1,D-Trp7,9,Leu11]substance P) on coronary resistance vessels were studied in isolated guinea pig hearts perfused at constant rate with isotonic buffer containing 20 or 40 mM KCl. Spantide (1 μM) caused a 20-fold rightward shift of the substance P (SP) dose-response curve for vasodilation with no change in maximum (KB=5.3×10-8 M). Bolus injections of 0.25 to 250 pmol spantide had no effect, but higher doses caused a brief vasodilation followed by a larger, more prolonged vasoconstriction. Histamine produced similar changes in perfusion pressure. Antihistamines (H1 and H2) reduced or blocked responses to spantide and histamine. These findings indicate spantide is a competitive antagonist to SP in guinea pig coronary resistance vessels. In addition, high doses of spantide can cause prominent vascular effects which are mediated by histamine.
Citation Information
Hoover, Donald B.. 1991. Effects of Spantide on Guinea Pig Coronary Resistance Vessels. Peptides. Vol.12(5). 983-988. https://doi.org/10.1016/0196-9781(91)90047-S PMID: 1724800 ISSN: 0196-9781