Evidence That 8-Methoxypsoralen (8-MOP) Is a T-Lymphocyte Immunomodulatory Agent
Document Type
Article
Publication Date
1-1-1988
Description
This study was designed to characterize the effects of the anti-psoraiatic compound 8-methoxypsoralen (8-MOP) on human lymphocyte function in vitro. Normal human peripheral blood mononuclear cells were stimulated with an optimal (1%) or a suboptimal (0.05%) concentration of phytohemagglutinin (PHA). At the optimal concentration of PHA, 8-MOP (140 μM) caused a delay in lymphocyte proliferation, interleukin-2 (IL-2) production/accumulation and IL-2 receptor expression. Addition of exogenous IL-2 to cultures stimulated with an optimal concentration of PHA did not overcome the delay of lymphocyte proliferation and IL-2 receptor expression. At the suboptimal concentration of PHA, 8-MOP (140 μM) caused a sustained inhibition of lymphocyte proliferation, IL-2 production/ accumulation and IL-2 receptor expression. Addition of exogenous IL-2 under these conditions restored the magnitude of lymphocyte proliferation and IL-2 receptor expression. However, the responses displayed the delayed lymphocyte proliferation and IL-2 receptor expression typical of cells incubated with 8-MOP and an optimal concentration of PHA.
Citation Information
Cox, George W.; Orosz, Charles G.; Lewis, Mark G.; Olsen, Richard G.; and Fertel, Richard H.. 1988. Evidence That 8-Methoxypsoralen (8-MOP) Is a T-Lymphocyte Immunomodulatory Agent. International Journal of Immunopharmacology. Vol.10(6). 773-781. https://doi.org/10.1016/0192-0561(88)90031-8 PMID: 3264275 ISSN: 0192-0561