Discrimination of Angiotensin II Receptor Subtype Distribution in the Rat Brain Using Non-Peptidic Receptor Antagonists
Document Type
Article
Publication Date
3-26-1991
Description
The non-peptidic angiotensin II receptor subtype selective antagonists, DuP 753 and PD123177, were used to characterize angiotensin II receptor binding sites in the rat brain. Competitive receptor autoradiography with 125I-Sar1-Ile8 angiotensin II defined a regional distribution of binding sites that were sensitive to either DuP 753 (designated AIIα subtype) or PD123177 (designated AIIβ subtype). Whereas most brain nuclei could be assigned to a category containing a predominant subtype, a multiple receptor subtype analysis indicated that some regions are homogeneous, while others contain a mixture of both AIIα and AIIβ subtypes.
Citation Information
Rowe, Brian P.; Grove, Kevin L.; Saylor, David L.; and Speth, Robert C.. 1991. Discrimination of Angiotensin II Receptor Subtype Distribution in the Rat Brain Using Non-Peptidic Receptor Antagonists. Regulatory Peptides. Vol.33(1). 45-53. https://doi.org/10.1016/0167-0115(91)90014-8 PMID: 2047544 ISSN: 0167-0115
