Variant T(8;21) Rearrangements in Acute Myeloblastic Leukemia of Childhood
Document Type
Article
Publication Date
7-15-1994
Description
In a collaborative cytogenetic analysis of blast cells from 638 children with acute myeloid leukemia, 74 (11.6%) of the patients had the typical t(8;21)(q22;q22), while seven (1.1%) had complex variant translocations also involving 8q22 and 21q22 as well as a variable chromosome. In each case with a complex rearrangement, the myeloid leukemic cells contained Auer rods and were classified as M2 in the French-American-British (FAB) system. These seven children had a median age of 14 years (range, 7.3-18.9 years), a median initial leukocyte count of 9.1 × 109/L (range, 2.5-142.2 × 109/L), and have survived leukemia free for a median of 23 months (1-41 months) after attaining complete remission. The variable chromosomes in these seven cases-1, 2, 7, 12, 13, 15, and 17-appeared to be randomly involved. The clinico-biologic features of our cases with a variant t(8;21) are consistent with those of the published cases with the standard t(8;21), and support the hypothesis that the critical genetic alteration produced by the t(8;21) is located on the derivative 8.
Citation Information
Gallego, M.; Carroll, A. J.; Gad, G. S.; Pappo, A.; Head, D.; Behm, F.; Ravindranath, Y.; and Raimondi, S. C.. 1994. Variant T(8;21) Rearrangements in Acute Myeloblastic Leukemia of Childhood. Cancer Genetics and Cytogenetics. Vol.75(2). 139-144. https://doi.org/10.1016/0165-4608(94)90166-X PMID: 8055478 ISSN: 0165-4608