Autoradiographic Localization of Substance P Binding Sites in Guinea-Pig Airways
Document Type
Article
Publication Date
1-1-1987
Description
The distribution of substance P (SP) binding sites in guinea-pig airway was examined by in vitro autoradiography with tritium and iodine-labeled SP. Specific SP binding sites were most abundant in tracheobronchial smooth muscle but were also detected in the mucosa/submucosa. Binding within the mucosa/submucosa was especially high in the region of glands. Binding of iodine-labeled SP to cartilage was negligible. Tritium-labeled SP bound non-specifically to airway cartilage. These observations are consistent with the proposed effects of SP-containing afferent nerves on airway resistance and vascular permeability. The localization of specific SP binding sites suggests that SP may also affect exocrine glands in the respiratory tract.
Citation Information
Hoover, Donald B.; and Hancock, John C.. 1987. Autoradiographic Localization of Substance P Binding Sites in Guinea-Pig Airways. Journal of the Autonomic Nervous System. Vol.19(2). 171-174. https://doi.org/10.1016/0165-1838(87)90009-9 PMID: 3036927 ISSN: 0165-1838
