Pharmacokinetics and Urinary Excretion of Clavulanic Acid After Oral Administration of Amoxicillin and Potassium Clavulanate
Document Type
Article
Publication Date
1-1-1984
Description
Abstract: Clavulanic acid is a β‐lactamase inhibitor which prevents microbial lactamase inactivation of β‐lactam antibiotics. The pharmacokinetics and urinary excretion of clavulanic acid were studied in eight healthy adult volunteers after oral administration of 500 mg amoxicillin and 125 mg potassium clavulanate. Serum and urine clavulanic acid concentrations were assayed using high‐performance liquid chromatography. Pharmacokinetic parameters were: t1/2β = 1.019 ± 0.090 hour, t1/2α = 0.276 ± 0.031 hour, lag time = 0.321 ± 0.018 hour, tmax = 1.042 ± 0.80 hour, Cmax = 2.098 ± 0.441 μg/ml, and AUC = 4.897 ± 0.979 μg · hr/ml. Cumulative urinary excretion of clavulanic acid (as percentage of dose administered) was: 14.05 ± 2.87 within 2 hours, 25.77 ± 3.98 within 4 hours, and 27.85 ± 4.27 within 6 hours after administration.
Citation Information
FERSLEW, KENNETH E.; DAIGNEAULT, ERNEST A.; ATEN, EDWARD M.; and ROSEMAN, JAMES M.. 1984. Pharmacokinetics and Urinary Excretion of Clavulanic Acid After Oral Administration of Amoxicillin and Potassium Clavulanate. The Journal of Clinical Pharmacology. Vol.24(10). 452-456. https://doi.org/10.1002/j.1552-4604.1984.tb01818.x PMID: 6511988 ISSN: 0091-2700