Effect of Temperature on Suppressor Cells in Chicken Spleen Cell Cultures
Document Type
Article
Publication Date
1-1-1984
Description
The plaque forming cell (PFC) response of in vivo primed chicken spleen cells to sheep erythrocytes (SRBC) at 37°C in vitro was much higher when antigen was added on Day 2 of culture than on Day 0, at the initiation of the incubation period. No such difference was observed when the cells were cultured at 40°C, in which case both responses were low. As shown previously the effect of delayed exposure to SRBC at 37°C was due to a disappearance of suppressor T cells in the absence of antigen, which did not occur at 40°C. Addition of concanavalin A on Day 0 could, even in the absence of SRBC, maintain the suppressor cell activity at 37°C. The results suggest that suppressor cell activity is very temperature dependent.
Citation Information
Bhogal, Balbir S.; Thorbecke, G. Jeanette; and Chi, David S.. 1984. Effect of Temperature on Suppressor Cells in Chicken Spleen Cell Cultures. Proceedings of the Society for Experimental Biology and Medicine. Vol.176(4). 414-418. https://doi.org/10.3181/00379727-176-41891 PMID: 6235523 ISSN: 0037-9727