Hypoparathyroidism in Wilson's Disease

Document Type

Letter

Publication Date

3-15-1984

Description

To the Editor: We enjoyed Dr. Scheinberg's perceptive editorial (Oct. 13 issue) on the value of investigating rare diseases.1 Elucidation of the mechanism of Wilson's disease and the subsequent successful treatment of this condition with penicillamine may also have shed considerable light on the etiologic mechanism of a rare birth defect, Ehlers–Danlos syndrome (dermatorrhexis cutis hyperelastica). This defect, which occurs spontaneously as a probable result of mendelian inheritance, also appears to be associated with maternal use of penicillamine in pregnancy.2 Penicillamine inhibits condensation of soluble tropocollagen because of affinity to the aldehyde. It chelates with unbound copper as well as.

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