Different Effects of 1, 10-Phenanthroline on Chronic Liver Injury Induced by Dimethylnitrosamine or Ethionine in Rats
Document Type
Article
Publication Date
5-16-1974
Description
Although 1, 10-phenanthroline (1, 10-P, 2 mg/100 g) prevents acute liver injury induced by dimethylnitrosamine (DMN), it does not protect female rats against liver damage caused by chronic treatment with DMN (2 mg/ 100 g). Liver damage was ascertained by measuring distribution and total activity of β-glucuronidase, rate of collagen synthesis, total collagen content of the liver, and amount of isocitric dehydrogenase (ICDH) in the serum. However, after simultaneous treatment with 1, 10-P and DMN for three weeks, the total amount of noncollagenous liver proteins and of microsomal protein and aniline hydroxylase activity were higher than in livers of rats receiving DMN alone. The proliferation of the smooth endoplasmic reticulum in livers of dogs treated for a 14-week period with 1, 10-P was demonstrated by ultrastructural techniques. Chronic liver injury induced by feeding female rats with a 0.3% d, 1-ethionine diet for five weeks was prevented by simultaneous administration of 1, 10-P (2 mg/100 g, i.p. 3 times weekly). It is suggested that when administered chronically, 1, 10-P acts as an inducer of the liver microsomal system and therefore increases the activity of liver mixed-function oxidases. This explains why chronic administration of 1, 10-P does not protect rats against injury caused by DMN. Ethionine hepatotoxicity, which does not seem to be related to the microsomal activity, is substantially decreased by as yet unknown mechanisms.
Citation Information
Chvapil, Milos; Carlson, Edward C.; Madden, John W.; and Peacock, Erle E.. 1974. Different Effects of 1, 10-Phenanthroline on Chronic Liver Injury Induced by Dimethylnitrosamine or Ethionine in Rats. Life Sciences. Vol.14(10). 1991-2002. https://doi.org/10.1016/0024-3205(74)90415-9 PMID: 4847798 ISSN: 0024-3205