α-Methyl-6-Aminodopamine: Depletion of Catecholamines in Mouse Brain and Peripheral Tissues
Document Type
Article
Publication Date
12-8-1980
Description
A new synthetic agent R, S-2-amino-1(2-amino-4, 5-dihydroxyphenyl) propane dihydrobromide, also referred to as α-methyl-6-aminodopamine (α-Me-6-ADA), has been found to produce acute (one day) and longer-term (seven day) depletion of norepinephrine (NE) levels in mouse brain and peripheral tissues. A 100 mg/kg dose of α-Me-6-ADA (i.v., free base) produced greater than 85% depletion of NE in the heart and spleen at one day and one week after treatment. Intracranially, α-Me-6-ADA (100 μg i.vtr.) depleted NE in the telencephalon and brain stem by 79% and 21% respectively at seven days. In addition DA was depleted by 45% in the ipsilateral striatum. The α-Me-6-ADA appears to have a relative selectivity for noradrenergic nerves, as an intracranial dose of 10 μg, which decreased NE in mouse whole brain by 52% at one day, failed to alter the DA content. These data suggest that α-Me-6-ADA may be a neurotoxin.
Citation Information
Kostrzewa, Richard M.; Fukushima, H.; Morrow, A.; Cohenour, P.; Hsi, T.; Lehr, R. E.; and Blank, C. L.. 1980. α-Methyl-6-Aminodopamine: Depletion of Catecholamines in Mouse Brain and Peripheral Tissues. Life Sciences. Vol.27(23). 2245-2250. https://doi.org/10.1016/0024-3205(80)90391-4 PMID: 7207017 ISSN: 0024-3205