Bright Artificial Light Produces Subsensitivity to Clonidine

Document Type

Article

Publication Date

1-1-1988

Description

The authors used a thermoregulation paradigm to test the hypothesis that chronic treatment with bright artificial light produces subsensitivity to the hypothermic effects of clonidine, an α2-agonist. One week of treatment produced blunting of the hypothermic response to clonidine (p < 0.00001). These findings are consistent with previous reports that somatic treatments for depression produce subsensitivity of the α2-receptor.

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