Comparison of A68 Levels in Alzheimer Diseased and Non-Alzheimer's Diseased Brain by Two ALZ50 Based Methods
Document Type
Article
Publication Date
10-15-1999
Description
A total of 61 human brain specimens were analyzed with both ELISA and Western Blot using the ALZ50 monoclonal antibody. The brain specimens included: Alzheimer's Disease (AD, n=31), AD/Down's (n=2), Normal (n=14), Parkinson's Disease (n=7), Huntington's chorea (n=2), Wernicke-Korsakov's Encephalopathy (n=3), and Motor Neuron Disease (n=2). The non-AD cases (n=28) had no detectable A68 by ELISA, and showed no A68 bands by Western blot. The AD cases (n=33), all were positive for A68 by the ELISA, but only 31 of 33 had visible A68 band by Western blot. Additionally, a method for solubilization of A68 is reported.
Citation Information
Miller, Barney E.. 1999. Comparison of A68 Levels in Alzheimer Diseased and Non-Alzheimer's Diseased Brain by Two ALZ50 Based Methods. Life Sciences. Vol.65(21). 2215-2222. https://doi.org/10.1016/S0024-3205(99)00486-5 PMID: 10576593 ISSN: 0024-3205