Effect of Hepatectomy on the Reticuloendothelial System of Septic Rats
Document Type
Article
Publication Date
1-1-1988
Description
The purpose of this study was to evaluate the function of the reticuloendothelial system (RES) of sham hepatectomy and 20% and 50% partial hepatectomy(PH 20%, PH 50%), with or without cecal ligation and puncture-induced sepsis. The animals were injected with 51 Chromium sheep red blood cells (SRBC) at 72 hours. SRBC half life (T1/2) was measured as an index of RES function and the percentage distribution of SRBC in liver, lung, and spleen was calculated. T1/2 was significantly prolonged in PH 50% rats and was associated with decreased radioactive uptake by the liver. Mortality was nil in the control groups and markedly increased in the presence of sepsis. The results suggest that decreased RES function following hepatectomy is dependent upon the proportion of liver removed and that sepsis further increased the mortality of hepatectomized animals.
Citation Information
Vo, Nghia M.; and Chi, David S.. 1988. Effect of Hepatectomy on the Reticuloendothelial System of Septic Rats. Journal of Trauma - Injury, Infection and Critical Care. Vol.28(6). 852-854. https://doi.org/10.1097/00005373-198806000-00025 PMID: 3385833 ISSN: 0022-5282