Biochemical Abnormalities of Muscle Ribosomes During Attacks of Hyperkalemic Periodic Paralysis
Document Type
Article
Publication Date
1-1-1973
Description
Three familial cases (a mother and 2 sons) with hyperkalemic periodic paralysis are presented. Myotonia (orbicularis oculi and hands) was noted all 3 cases. Exposure to cold produced weakness in the 2 older patients. An oral KCl loading test induced paroxysmal weakness in all 3 cases. Ribosomes isolated in 2 cases from biopsied muscle during the induced attacks showed definite increases of protein synthesis in a group of rather heavy muscle polyribosomes. Electron microscopy revealed in both cases scattered small membrane-bound vacuoles, subsarcolemmal aggregates of myotubules, glycogen particles and occasional filamentous bodies.
Citation Information
Ionasescu, V.; Zellweger, H.; Schochet, S. S.; and Conway, T. W.. 1973. Biochemical Abnormalities of Muscle Ribosomes During Attacks of Hyperkalemic Periodic Paralysis. Journal of the Neurological Sciences. Vol.19(4). 389-398. https://doi.org/10.1016/0022-510X(73)90036-1 PMID: 4724816 ISSN: 0022-510X