Dominant Inheritance of Cerebral Gigantism

Creator(s)

Jonathan Zonana, University of California, Los Angeles
Juan F. Sotos, University of California, Los Angeles
Carolyn A. Romshe, Quillen-Dishner College of Medicine
Delbert A. Fisher, University of California, Los Angeles
M. Jocelyn Elders, UAMS Medical Center
David L. Rimoin, University of California, Los Angeles

Document Type

Article

Publication Date

1-1-1977

Description

Cerebral gigantism is a syndrome consisting of characteristic dysmorphic features, accelerated growth in early childhood, and variable degrees of mental retardation. Its etiology and pathogenesis have not been defined. Three families are presented with multiple affected members. The vertical transmission of the trait and equal expression in both sexes in these families indicates a genetic etiology with a dominant pattern of inheritance, probably autosomal. As in previously reported cases, extensive endocrine evaluation failed to define the pathogenesis of the accelerated growth present in this disorder.

Citation Information

Zonana, Jonathan; Sotos, Juan F.; Romshe, Carolyn A.; Fisher, Delbert A.; Elders, M. Jocelyn; and Rimoin, David L.. 1977. Dominant Inheritance of Cerebral Gigantism. The Journal of Pediatrics. Vol.91(2). 251-256. https://doi.org/10.1016/S0022-3476(77)80822-6 PMID: 889595 ISSN: 0022-3476