Document Type
Article
Publication Date
2-6-1998
Description
Oncogenic p21(ras) proteins can only exert their stimulation of cellular proliferation when plasma membrane-associated. This membrane association has an absolute requirement for post-translational modification with isoprenoids. The mechanism by which isoprenoids participate in the specific association of p21(ras) with plasma membranes is the subject of this report. We present in vitro evidence for a plasma membrane binding protein for p21(ras) that can recognize the isoprenoid substituent and, therefore, may facilitate the localization of p21(ras).
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Citation Information
Siddiqui, Afzal A.; Garland, John R.; Dalton, Marguerite B.; and Sinensky, Michael. 1998. Evidence for a High Affinity, Saturable, Prenylation-Dependent p21(Ha- Ras) Binding Site in Plasma Membranes. Journal of Biological Chemistry. Vol.273(6). 3712-3717. https://doi.org/10.1074/jbc.273.6.3712 PMID: 9452502 ISSN: 0021-9258
Copyright Statement
© 1998 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.